Combine the ground beef, salt, pepper, onion powder, and garlic powder in a medium bowl and mix until incorporated.
Form into 4 equally sized patties about 1/2" thick. Make a small indent in the middle of each patty with your thumb. This way the burgers will cook evenly.
Preheat the air fryer to 375°F.
Add the patties in a single layer to the basket
Cook for 9 to 11 minutes or until the beef reaches 160°F.
Add cheese if desired, and cook just until the cheese melts, about 30 seconds.